Abstract Library
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ENETS Abstract Search
Introduction: Three molecular subtypes of pancreatic neuroendocrine tumours (PanNETs) have been described: insulinoma-like, intermediate and metastasis-like primary (MLP). The Latter is a non-functional tumours with highly metastatic potential. A mouse model of PanNET showed that MLP subtype has two different pathways of progression including stem/progenitor and epithelial-to-mesenchymal transition. However, the evolution of metastasis in patients requires further studies.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Sadanandam A
Authors: Sadanandam A, Lawlor R, Nyamundanda G, Ragulan C, Scarpa A,
Keywords: Pancreatic neuroendocrine tumors, metastasis, metastatic evolution, early metastasis, recurrence, prognosis, Patient tumours, cause and effect relationship, computational modeling, molecular subtypes, stages, metastatic potential,
Introduction: Metabolic changes are observed in early and late stages of Pancreatic Neuroendocrine Tumors (PanNET) in mouse models. In human PanNET, RNA-expression analysis showed changes in glucose metabolism in more aggressive PanNET.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Bräutigam K
Authors: Straub J, Bräutigam K, Di Domenico A, Galván J, Maire R,
Keywords: metabolism, microadenoma, immunohistochemistry, pancreas, tumor, mct4, relapse,
#2834 Tumor-Promoting Effects of the Transcriptional Regulator CUX1 in PanNET
Introduction: Previously, we identified CUX1 as mediator of metastatic behaviour and poor differentiation in human insulinomas. CUX1 mediated tumor-promoting functions via enhancing proliferation, resistance to apoptosis and angiogenesis in-vitro and in-vivo.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Weißbach J
Authors: Weißbach J, Schmitz R, Haybäck J, Perren A, Blank A,
Keywords: CUX1, RIP1Tag2, DAPK1, Apoptosis, Tumor Progression,
Introduction: One of the main consequences of inhibition of neovessel growth produced by angiogenesis inhibitors is increased intratumor hypoxia. Growing evidence indicates that tumor cells escape from this hypoxic environment to better nourished locations, presenting hypoxia as a positive stimulus for invasion. Particularly, anti-VEGF/R therapies produce hypoxia-induced invasion and metastasis in a spontaneous mouse model of pancreatic neuroendocrine cancer, RIP1-Tag2.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Casanovas O
Authors: Zuazo-Gaztelu I, Pàez-Ribes M, Carrasco P, Martín-Mitjana L, Sallaberry J,
Keywords: Antiangiogenic therapies, Semaphorin 4D, Mouse models of NETs, Invasion and metastasis,
Introduction: Pancreatic neuroendocrine tumors (PNETs) comprise a heterogeneous group of endocrine tumors. Previous studies showed that mutations of p53 are extremely rare; whereas genetic changes of MEN1 frequently occur and are correlated with poor prognosis in PNET. Still, their roles in tumorigenesis remain elusive.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Capodanno Y
Authors: Capodanno Y, Chen Y, Hiraoka N, Yokoyama A, Schrader J,
Keywords: MEN1, p53, Notch pathway, biomarkers, carcinogenesis, PNET,